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THE CHARACTERISTICS OF EC SUPPLY CHAINS EC supply chains need to deliver small quantities to a very large number of customers Also, it is very dif cult to forecast demand due to lack of experience and to the fact that many vendors sell some or mostly customized products New dot-com companies do not have any existing supply chain operations; they are starting from scratch (Click-and-mortar companies, in contrast, have existing supply chains and so have a bit of a head start) When a company sells online direct to customers it must take care of the following activities: quickly nd the products to be shipped, and pack them; arrange for the packages to be delivered quickly to the customer s door; collect the money from every customer, either in advance, COD (collect on delivery), or by billing the individual; and handle the return of unwanted or defective products.

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It may be dif cult to ful ll these activities both effectively and ef ciently For this reason, both online companies and click-and-mortar companies have dif culties in their online-related supply chains Let s begin by looking at order ful llment ORDER FULFILLMENT Order ful llment refers not only to providing what customers ordered and doing it on time, but also to providing all related customer service For example, the customer must receive assembly and operating instructions for the appliance he or she just purchased This can be done by including a paper document with the product or by providing the instructions on the Web (A nice example is available at livemanualscom) In addition, if the customer is not happy with a product, an exchange or return must be arranged.

FIGURE 10-3 Fatty acid transporters in the plasma membrane. FATP, fatty acid transport protein; FABP,,, fatty acid-binding protein of the plasma membrane.

Thus, while order ful llment is basically a part of the back-of ce operations, it is strongly related to front-of ce operations as well When dot-com operations were still quite new, e-tailers faced continuous problems with order ful llment, especially during the holiday season The problems included inability to deliver on time, delivering wrong items, paying too much for deliveries, and heavily compensating unhappy customers Taking orders over the Internet for some e-tailers proved to be the easy part of B2C e-commerce Ful llment to customers doors was the harder part The e-tailers who have survived have proved that they have learned from past mistakes and are learning how to solve their order ful llment problems As a matter of fact, many e-tailers have experienced ful llment problems since they started EC Amazon.

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com, for example, which initially operated as a totally online company, added physical warehouses in order to expedite deliveries and reduce its order ful llment costs Woolworths of Australia, a large supermarket that added online services, had serious dif culties with order ful llment and delivery of fresh foods, and had to completely restructure its delivery system Several factors can be responsible for delays in deliveries They range from inability to accurately forecast demand, to ineffective supply chains of the e-tailers Similar problems exist also in off-line businesses However, one EC is more typically based on the concept of pull operations, which begin with an order, frequently a customized one (This is in contrast with traditional retailing that begins with a production to inventory, which is then pushed to customers.

) In the pull case, it is more dif cult to forecast demand, due to unique demands of customized orders and lack of suf cient years of experience (see Appendix 31) Another order ful llment problem in e-commerce is that the goods need be delivered to the customer s door, with small quantities to each customer, whereas in brick-and-mortar retailing, the customers come to the stores to get.

Hepatocytes contain two distinct HMG-CoA synthases: a cytosolic enzyme that is involved in cholesterol synthesis, and a mitochondria1 enzyme which functions in the pathway of ketone body synthesis.

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